Abstract #0419

Short-term cerebral blood flow reduction induced “apparent” brain tissue density reduction

Qiu Ge¹, Wei Peng¹, Yong Zhang², Yu-Feng Zhang¹, Thomas Liu³, Xuchu Weng¹, and Ze Wang¹

¹Hangzhou Normal University, Hangzhou, China, People's Republic of, ²GE Healthcare, MR Research China, Beijing, Shanghai, China, People's Republic of, ³University of California San Diego, San Diego, CA, United States

MRI-identified short-term brain tissue changes have been in debate because of the lack of solid evidence of neurogenesis. Cerebral blood flow (CBF) has been traced as one contributing factor. We used caffeine to modulate CBF and to subsequently examine brain tissue change using MRI. Both CBF reduction and grey matter decrease were observed after caffeine ingestion, which were further related to each other in some brain regions. The data provide direct evidence for the CBF contribution to the short-term apparent tissue changes.

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