Abstract #0420

Rethinking macro-vascular artifacts from single post-label delay ASL: can we extract a "free-lunch" arterial transit time metric?

Henk Mutsaerts¹, Lena Vaclavu², Jan-Willem van Dalen², Andrew Robertson¹, Paul Groot², Mario Masellis¹, Edo Richard², Aart J Nederveen², and Bradley MacIntosh¹

¹Sunnybrook Research Institute, Toronto, ON, Canada, ²Academic Medical Center, Amsterdam, Netherlands

In this work, we propose a novel method to infer an ATT estimate from the spatial signal distribution of single-time point ASL CBF maps, using a spatial Coefficient of Variation (CoV). In a large population of elderly with hypertension, we compare crushed (C CBF) and non-crushed CBF maps (NC CBF), from which we derive C CoV and NC CoV, and the FEAST-based ATT estimate. These explorative results show that both ATT and BMI are associated with NC CoV but not with NC CBF, suggesting that ATT ‒ as estimated by the spatial CoV ‒ might serve as a global biomarker of cerebrovascular disease.

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