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Abstract #0426

Differential effects of ketamine-propofol vs propofol anaesthesia on cerebral perfusion in children

Ruth L O'Gorman1, Philipp Buehler2, Carola Sabandal2, Ianina Scheer3, Malek Makki1, Markus Weiss2, Christian Kellenberger3, and Achim Schmitz2

1Center for MR Research, University Children's Hospital, Zurich, Switzerland, 2Anaesthesia, University Children's Hospital, Zurich, Switzerland, 3Radiology, University Children's Hospital, Zurich, Switzerland

Anaesthetics such as those used for sedation in pediatric MRI affect cerebral blood flow and hemodynamics to varying degrees. This study examines differences in cerebral perfusion in children undergoing elective MRI under sedation with propofol vs. a combination of propofol and ketamine. Children induced for sedation with ketamine demonstrated on average 14% higher whole brain perfusion values than those induced for sedation with propofol, confirming that ketamine and propofol exert a differential effect on brain activity and hemodynamics.

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