Abstract #0427

Evidencing different neurochemical profiles between thalamic nuclei using 2D-semilaser 1H-MRSI at 7T

Maxime Donadieu^1,2,3, Yann Le Fur^1,2, Sylviane Confort-gouny^1,2, Arnaud Le Troter^1,2, Maxime Guye^1,2, and Jean-Philippe Ranjeva^1,2

¹CRMBM UMR 7339, Aix Marseille Université CNRS, Marseille, France, Metropolitan, ²CEMEREM Pole d'Imagerie, AP-HM CHU Timone, Marseille, France, Metropolitan, ³Siemens Healthcare, Saint-Denis, France, Metropolitan

Using 2D-semilaser 1H-MRSI sequence centered on thalamus and acquired at 7T in 10 healthy volunteers, we demonstrate that the neurochemical profiles (relative NAA, Cr and Cho levels) are different between pulvinar, ventral-lateral, dorsal-medial and anterior nuclei. Moreover, left/right differences in neurochemical profiles, especially for NAA levels, showed a left NAA lateralization for the ventral-lateral nucleus and the pulvinar and in contrast higher right NAA levels in the anterior nucleus. These results suggest that the various neurochemical profiles of these thalamic nuclei may be related to their functional specificity.

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