Abstract #0439

In vivo quantification of antimitotic-treatment-induced microstructural changes using temporal diffusion

xiaoyu jiang¹, hua li¹, jingping Xie¹, ping zhao¹, junzhong xu¹, dineo khabele², and John Gore¹

¹vanderbilt university institute of imaging science, nashville, TN, United States, ²vanderbilt university, nashville, TN, United States

Reliable and sensitive methods for assessing the response of tumors to treatment are critical in rapid selection of the most appropriate therapy for individual patients, and development of novel therapies. Temporal diffusion spectroscopy, which measures the variation of apparent diffusion coefficient (ADC) over a range of effective diffusion times, is proposed to measure tumor microstructural variations in response to chemotherapy. The proposed method is shown to detect the increase in cell size in response to the antimitotic-treatment in both well-characterized cell culture and solid tumors in vivo. The MR observations are supported by flow cytometric, microscopic, and histological analysis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.