Meeting Banner
Abstract #0439

In vivo quantification of antimitotic-treatment-induced microstructural changes using temporal diffusion

xiaoyu jiang1, hua li1, jingping Xie1, ping zhao1, junzhong xu1, dineo khabele2, and John Gore1

1vanderbilt university institute of imaging science, nashville, TN, United States, 2vanderbilt university, nashville, TN, United States

Reliable and sensitive methods for assessing the response of tumors to treatment are critical in rapid selection of the most appropriate therapy for individual patients, and development of novel therapies. Temporal diffusion spectroscopy, which measures the variation of apparent diffusion coefficient (ADC) over a range of effective diffusion times, is proposed to measure tumor microstructural variations in response to chemotherapy. The proposed method is shown to detect the increase in cell size in response to the antimitotic-treatment in both well-characterized cell culture and solid tumors in vivo. The MR observations are supported by flow cytometric, microscopic, and histological analysis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here