Abstract #0440

Quantitative Arterial Spin Labeled (ASL) Perfusion and Diffusion Weighted Imaging (DWI) in Clear Cell Renal Cell Carcinoma: Correlation with Heterogeneous Tumor Vascularity and Cellularity at Histopathology

Qing Yuan¹, Payal Kapur^2,3, Yue Zhang¹, Yin Xi¹, Sabina Signoretti⁴, Ananth Madhuranthakam^1,5, Ivan E Dimitrov^5,6, Jeffrey A Cadeddu^1,3, Vitaly Margulis³, and Ivan Pedrosa^1,5

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Pathology, UT Southwestern Medical Center, Dallas, TX, United States, ³Urology, UT Southwestern Medical Center, Dallas, TX, United States, ⁴Pathology, Brigham and Women's Hospital, Boston, MA, United States, ⁵Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ⁶Philips Medical Systems, Cleveland, OH, United States

We investigated intratumor heterogeneity of perfusion and diffusion in vivo using ASL and DWI in clear cell renal cell carcinoma (ccRCC), and correlated these measures with tumor vascularity and cellularity at histopathology. Focused histopathologic analysis of tumor areas corresponding to high perfusion regions on ASL confirmed higher microvessel density (MVD) and demonstrated higher cellularity compared to tumor areas with low perfusion on ASL. A negative correlation between MRI diffusion measures and tissue cellularity further supports noninvasive MRI techniques as potential imaging biomarker in ccRCC for assessment of heterogeneity in tumor angiogenesis and microenvironment in vivo.

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