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Abstract #0441

Apparent diffusion coefficient of hyperpolarized lactate reports on lactate production and efflux in renal cell carcinomas

Renuka Sriram1, Bertram Koelsch1, Jeremy W Gordon1, Mark Van Criekinge1, Celine Baligand1, Robert A Bok1, Dan B Vigneron1, Kayvan R Keshari2, Peder E Larson1, Zhen Jane Wang1, and John Kurhanewicz1

1University of California, San Francisco, San Francisco, CA, United States, 2Memorial Sloan-Kettering Cancer Center, New York, NY, United States

This study demonstrated that diffusion weighted HP 13C MRI can provide an estimate of the amount of extra- versus intracellular HP 13C lactate based on its apparent diffusion coefficient (ADC). In metastatic renal cell carcinoma, a large portion of the HP 13C lactate signal arises from an extracellular lactate pool, based on reliable estimates of ADC in the same cell line in a the MR compatible bioreactor. The juxtaposition of cells in bioreactor and the in vivo animal model is a powerful tool for interpretation of the hyperpolarized ADC measurements. This unique combination can be further extended to investigate the relationship between lactate transport and tumor metastatic potential.

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