Abstract #0441

Apparent diffusion coefficient of hyperpolarized lactate reports on lactate production and efflux in renal cell carcinomas

Renuka Sriram¹, Bertram Koelsch¹, Jeremy W Gordon¹, Mark Van Criekinge¹, Celine Baligand¹, Robert A Bok¹, Dan B Vigneron¹, Kayvan R Keshari², Peder E Larson¹, Zhen Jane Wang¹, and John Kurhanewicz¹

¹University of California, San Francisco, San Francisco, CA, United States, ²Memorial Sloan-Kettering Cancer Center, New York, NY, United States

This study demonstrated that diffusion weighted HP ¹³C MRI can provide an estimate of the amount of extra- versus intracellular HP ¹³C lactate based on its apparent diffusion coefficient (ADC). In metastatic renal cell carcinoma, a large portion of the HP ¹³C lactate signal arises from an extracellular lactate pool, based on reliable estimates of ADC in the same cell line in a the MR compatible bioreactor. The juxtaposition of cells in bioreactor and the in vivo animal model is a powerful tool for interpretation of the hyperpolarized ADC measurements. This unique combination can be further extended to investigate the relationship between lactate transport and tumor metastatic potential.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.