Abstract #0447

DCE-MRI High-resolution Metabolic Prostate Imaging is Insensitive to AIF Uncertainty

Xin Li¹, Mark G. Garzotto^2,3, Fergus V. Coakley⁴, Brendan Moloney¹, William J. Woodward¹, Yiyi Chen⁵, Wei Huang¹, William D. Rooney¹, and Charles S. Springer, Jr.¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Portland VA Medical Center, Portland, OR, United States, ³Urology, Oregon Health & Science University, Portland, OR, United States, ⁴Department of Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States, ⁵Division of Biostatistics, Dept. of Public Health and Preventive Medicine, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, United States

Accurate arterial input function (AIF) measurement in Dynamic Contrast Enhanced MRI (DCE-MRI) remains challenging. This hinders DCE-MRI’s wider adoption. Since the contrast reagent (CR) is detected indirectly through water proton R₁ relaxation rate constant change, DCE-MRI intrinsically works as a dual-probe (CR and water) method. In this study, we demonstrate that while the common pharmacokinetic parameters associated with CR extravasation are highly sensitive to AIF accuracy, the transcytolemmal water exchange parameter is not. With the recent correlation of water exchange kinetics and cellular metabolic activity, this current work demonstrates the practicability of high-resolution metabolic imaging of the prostate.

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