Abstract #0446

Differential tumor perfusion in vivo on Arterial Spin Labeled MRI correlates with heterogeneity in the molecular phenotype of clear cell Renal Cell Carcinoma

Manoj Bhasin¹, Rupal Bhatt², Phillip M Robson³, Deepa Rajamani¹, Sabina Signoretti⁴, David C Alsop³, and Ivan Pedrosa⁵

¹Division of Interdisciplinary Medicine & Biotechnology, and Genomics, Proteomics, Bioinformatics and Systems Biology Center, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States, ²Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States, ³Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States, ⁴Pathology, Brigam and Women's Hospital, Boston, MA, United States, ⁵Radiology, UT Southwestern Medical Center, Dallas, TX, United States

We used Arterial Spin Labeled (ASL) MRI to explore the association between heterogeneous in vivo perfusion in clear cell renal cell carcinoma (ccRCC) and the underlying genomic profile to identify key genes linked to tumor angiogenesis. Ephrin-A5 (EFNA5) expression correlated with ASL perfusion (R2 = 0.504, P value= .002) and exhibited highest significant differences between low and high perfusion (Fold Change = 2.88, P value < 0.02). Higher expression of EFNA5 is associated with poor 3 and 5 years survival (P = 0.0009). We propose MRI-based targeted tissue sampling to characterize the heterogeneous genetic alterations driving angiogenesis in ccRCC.

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