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Abstract #0445

Non-enhanced Hypercellular Volume in Glioblastoma identified by High b-value Diffusion Weighted Imaging

Yue Cao1,2, Daniel Wahl1, Priyanka Pramanik1, Michelle Kim1, Theodore S Lawrence1, and Hemant Parmar2

1Radiaiton Oncology, University of Michigan, Ann Arbor, MI, United States, 2Radiology, University of Michigan, Ann Arbor, MI, United States

It is a challenge to differentiate non-enhanced components of glioblastoma (GBM) from edema and normal tissue using conventional MRI. The ill-differentiation could lead to inadequate treatment for GBM by surgery and radiation therapy. This study evaluated the enhanced and non-enhanced hypercellular volume (HCV) of GBM identified by high b-value diffusion weighted (DW) imaging with gross tumor volume defined on post-Gd T1 weighted images, abnormality volume on T2 FLAIR images, high dose coverage planned according to conventional MRI, and progression. This study found that the HCV was an aggressive component of GBM and predicted progression free survival.

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