Abstract #0445

Non-enhanced Hypercellular Volume in Glioblastoma identified by High b-value Diffusion Weighted Imaging

Yue Cao^1,2, Daniel Wahl¹, Priyanka Pramanik¹, Michelle Kim¹, Theodore S Lawrence¹, and Hemant Parmar²

¹Radiaiton Oncology, University of Michigan, Ann Arbor, MI, United States, ²Radiology, University of Michigan, Ann Arbor, MI, United States

It is a challenge to differentiate non-enhanced components of glioblastoma (GBM) from edema and normal tissue using conventional MRI. The ill-differentiation could lead to inadequate treatment for GBM by surgery and radiation therapy. This study evaluated the enhanced and non-enhanced hypercellular volume (HCV) of GBM identified by high b-value diffusion weighted (DW) imaging with gross tumor volume defined on post-Gd T1 weighted images, abnormality volume on T2 FLAIR images, high dose coverage planned according to conventional MRI, and progression. This study found that the HCV was an aggressive component of GBM and predicted progression free survival.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.