Deborah K. Hill1,2, Andreas Heindl3, Daniel N. Rodrigues3, Øystein Størkersen2, Yinyin Yuan3, Siver A. Moestue 1,2, Martin O. Leach3, Tone F. Bathen1, David J. Collins3, and Matthew D. Blackledge3
1Norwegian University of Science and Technology, Trondheim, Norway, 2St. Olavs University Hospital, Trondheim, Norway, 3The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom
An
increased ADC can imply reduced cellularity; DWI is considered a useful tool
for assessing tumour treatment response, although there is little validation of
this relationship in cancer. We compared ADC, cellularity, and extracellular porosity using
a transgenic adenocarcinoma of
the mouse prostate model. ADC values were derived from DWI data, and
cellularity was assessed from histology using novel visualisation and
segmentation tools. We investigated the relationship between extracellular
porosity and ADC, and validated our findings using cell segmentation analysis
of histology slides. This analysis is useful to inform on tissue cellularity
for cases where histology samples are not available.
