Abstract #0444

Exploring the Relationship between MR-derived Apparent Diffusion Coefficient, Cellularity, and Extracellular Porosity: A Preliminary Animal Study in Prostate Cancer

Deborah K. Hill^1,2, Andreas Heindl³, Daniel N. Rodrigues³, Øystein Størkersen², Yinyin Yuan³, Siver A. Moestue ^1,2, Martin O. Leach³, Tone F. Bathen¹, David J. Collins³, and Matthew D. Blackledge³

¹Norwegian University of Science and Technology, Trondheim, Norway, ²St. Olavs University Hospital, Trondheim, Norway, ³The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom

An increased ADC can imply reduced cellularity; DWI is considered a useful tool for assessing tumour treatment response, although there is little validation of this relationship in cancer. We compared ADC, cellularity, and extracellular porosity using a transgenic adenocarcinoma of the mouse prostate model. ADC values were derived from DWI data, and cellularity was assessed from histology using novel visualisation and segmentation tools. We investigated the relationship between extracellular porosity and ADC, and validated our findings using cell segmentation analysis of histology slides. This analysis is useful to inform on tissue cellularity for cases where histology samples are not available.

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