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Abstract #0443

Combined MRI and optical CT imaging of tumour vasculature in a preclinical model of neuroblastoma

Ciara M McErlean1, Yann Jamin1, Jessica KR Boult1, Alexander Koers1, Laura S Danielson1, David J Collins1, Martin O Leach1, Simon P Robinson1, and Simon J Doran1

1Institute of Cancer Research, London, United Kingdom

This study compares MRI functional measurements of the vasculature in a preclinical model of neuroblastoma with ex vivo optical CT high-resolution 3D imaging of the functional vasculature using India ink staining. MRI showed a heterogeneously perfused tumour with high fractional blood volume and vessel size index, characteristic of hypervascular neuroblastoma. The high resolution optical CT images allowed visualisation of individual vessels and corroborated the MRI findings. With improved registration, optical CT could help validate MRI functional biomarkers of the vasculature and accelerate both our understanding of vessel biology and the evaluation of vascular-targeted treatment in cancer and other vascular-related pathologies.

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