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Abstract #0449

Development of nitroxide-based theranostics probes for brain redox research by MRI

Miho C Emoto1, Shingo Sato2, and Hirotada G Fujii1

1Sapporo Medical Univeristy, Sapporo, Japan, 2Yamagata University, Yonezawa, Japan

Theranostics probes, which have both therapeutic and diagnostic imaging capabilities in one dose, show great promise for use in MRI examinations. In the present study, we synthesized nitroxide-based theranostics probes by connecting anti-inflammatory drugs, ibuprofen and ketoprofen, to nitroxides that act as T1 contrast agents in MRI. MRI of mouse heads after injection of these synthesized probes showed that they worked as T1 contrast agents in mouse brains. Production of nitric oxide in septic mouse brains was remarkably inhibited by the addition of these probes, indicating that they also acted as anti-inflammatory drugs.

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