Abstract #0450

Initial Experience in a Pilot Study of Blood-Brain Barrier Opening for Chemo-Drug Delivery to Brain Tumors by MR-Guided Focused Ultrasound

Yuexi Huang¹, Ryan Alkins², Martin Chapman³, James Perry⁴, Arjun Sahgal⁵, Maureen Trudeau⁶, Todd Mainprize⁷, and Kullervo Hynynen^1,2

¹Sunnybrook Research Institute, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Department of Anaesthesia, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Division of Medical Oncology and Hematology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁷Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

In the first case of a pilot clinical study to establish the feasibility, safety and preliminary efficacy of focused ultrasound to temporarily open blood brain barrier (BBB) to deliver chemotherapy to brain tumors, BBB was successfully opened at two targeted volumes close to the peripheral margin of the tumor, approximately 4cm lateral from the midline of the brain. This may provide a new way to deliver therapeutic agents into brain for the treatment of tumors and other brain diseases.

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