Abstract #0460

Accurate T1 mapping in patients with Pulmonary Hypertension and age matched volunteers using synthetic image based registration

Laura Claire Saunders¹, Neil J Stewart¹, Charlotte Hammerton¹, David Capener¹, Valentina O Puntmann², David G Kiely³, Martin J Graves⁴, Andy Swift¹, and Jim M Wild¹

¹Academic Unit of Radiology, The University of Sheffield, Sheffield, United Kingdom, ²Department of Cardiovascular Imaging, Kings College London, London, United Kingdom, ³The University of Sheffield, Sheffield, United Kingdom, ⁴University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom

Patients with suspected pulmonary hypertension (n=94) and healthy volunteers (n=26) underwent T1 mapping of the right ventricle with a Modified Look Locker inversion recovery (MOLLI) sequence at 1.5T. MOLLI images were registered using pairwise registration to synthetic images produced using a simplified inversion recovery model to correct cardiac or respiratory motion. 89% of patients and 100% of healthy volunteers were successfully registered, with mean T1s of 1.00±0.10s and 0.97±0.06s (septal), 1.05±0.11s and 0.97±0.06s (right ventricular insertion point) and 1.02±0.11s and 1.04±0.13s (right ventricular free wall) respectively.

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