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Abstract #0460

Accurate T1 mapping in patients with Pulmonary Hypertension and age matched volunteers using synthetic image based registration

Laura Claire Saunders1, Neil J Stewart1, Charlotte Hammerton1, David Capener1, Valentina O Puntmann2, David G Kiely3, Martin J Graves4, Andy Swift1, and Jim M Wild1

1Academic Unit of Radiology, The University of Sheffield, Sheffield, United Kingdom, 2Department of Cardiovascular Imaging, Kings College London, London, United Kingdom, 3The University of Sheffield, Sheffield, United Kingdom, 4University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom

Patients with suspected pulmonary hypertension (n=94) and healthy volunteers (n=26) underwent T1 mapping of the right ventricle with a Modified Look Locker inversion recovery (MOLLI) sequence at 1.5T. MOLLI images were registered using pairwise registration to synthetic images produced using a simplified inversion recovery model to correct cardiac or respiratory motion. 89% of patients and 100% of healthy volunteers were successfully registered, with mean T1s of 1.00±0.10s and 0.97±0.06s (septal), 1.05±0.11s and 0.97±0.06s (right ventricular insertion point) and 1.02±0.11s and 1.04±0.13s (right ventricular free wall) respectively.

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