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Abstract #0469

Nanodiamond Imaging with Room Temperature Dynamic Nuclear Polarization

David E J Waddington1,2,3, Mathieu Sarracanie2,3,4, Huiliang Zhang3,5, Torsten Gaebel1, David R Glenn3,5, Ewa Rej1, Najat Salameh2,3,4, Ronald L Walsworth3,5, David J Reilly1, and Matthew S Rosen2,3,4

1School of Physics, University of Sydney, Sydney, Australia, 2A.A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Department of Physics, Harvard University, Cambridge, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Harvard-Smithsonian Center for Astrophysics, Cambridge, MA, United States

Overhauser-enhanced MRI (OMRI) is a double resonance technique that has been developed to image free radicals in vivo. Here, we use an ultra-low field MRI scanner with a highly efficient b-SSFP OMRI protocol to image synthetic nanodiamonds (NDs) in water at room temperature. Surprisingly, we find that high contrast can be generated via the Overhauser effect due to paramagnetic impurities in the ND. Given the already established application of ND as a biocompatible platform for drug delivery, these results are encouraging for applications based on the non-invasive tracking of nanoparticles using MRI.

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