Abstract #0470

Imaging Spermine using LnDOTP5-Towards a Noninvasive Staging of Prostate Cancer

Abiola Olatunde¹, Taylor Fuss¹, Phillip Zhe Sun¹, Leo L Cheng¹, and Peter Caravan¹

¹Massachusetts General Hospital, Boston, MA, United States

Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Previous studies have indicated the utility of spermine as a potential biomarker for prostate cancer; however, quantifying spermine using MRS is difficult due to overlapping chemical shifts of spermine with other metabolites. We used LnDOTP^5-, an anionic lanthanide macrocyclic complex, to form a stable ternary complex with positively-charged spermine to selectively shift spermine MR resonances. Here we report the affinity of different LnDOTP^5- complexes for spermine and the effect of complex formation on spermine MR resonances in both D₂O and serum solutions and intact human prostate tissue.

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