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Abstract #0470

Imaging Spermine using LnDOTP5-Towards a Noninvasive Staging of Prostate Cancer

Abiola Olatunde1, Taylor Fuss1, Phillip Zhe Sun1, Leo L Cheng1, and Peter Caravan1

1Massachusetts General Hospital, Boston, MA, United States

Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Previous studies have indicated the utility of spermine as a potential biomarker for prostate cancer; however, quantifying spermine using MRS is difficult due to overlapping chemical shifts of spermine with other metabolites. We used LnDOTP5-, an anionic lanthanide macrocyclic complex, to form a stable ternary complex with positively-charged spermine to selectively shift spermine MR resonances. Here we report the affinity of different LnDOTP5- complexes for spermine and the effect of complex formation on spermine MR resonances in both D2O and serum solutions and intact human prostate tissue.

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