Meeting Banner
Abstract #0471

Molecular imaging of inflammation and extracellular matrix remodelling after myocardial infarction

Isabel Ramos1,2, Markus Henningsson1, Maryam Nezafat1, Begoña Lavin1,2, Pierre Gebhardt1, Andrea Protti1,2, Sara Lacerda1,2, Silvia Lorrio1,2, Alkystis Phinikaridou1,2, Ulrich Flögel3, Ajay M. Shah2, and René M. Botnar1,2

1Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Cardiovascular Division, The British Heart Foundation Centre of Excellence, King's College London, London, United Kingdom, 3Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Optimal post-MI healing relies on a suitable degree of inflammation and its timely resolution, which is directly related to a well-orchestrated degradation and deposition of extracellular matrix (ECM) proteins, leading to cardiac remodeling. Here we explored the merits of multinuclear 1H/19F MRI for the simultaneous assessment of cardiac inflammation and subsequent remodelling in a murine model of MI. To investigate inflammatory cell recruitment into injured myocardium, a 19F containing nanoparticle that is avidly taken up by macrophages was used1. To evaluate changes of elastin content in the ECM post-MI, a small molecular weight gadolinium-based elastin-specific MR contrast agent was investigated2.

This abstract and the presentation materials are available to members only; a login is required.

Join Here