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Abstract #0472

Correlation of Hyperpolarized 13C-Lactate Measurements and Ex Vivo NMR using a [3-13C]Pyruvate Injection

Casey Y. Lee1,2, Justin Y. C. Lau1,2, Albert P. Chen3, Yi-Ping Gu2, and Charles H. Cunningham1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3GE Healthcare, Toronto, ON, Canada

Lactate has been proposed as a potential marker to non-invasively predict cancer progression and monitor response to the therapy. Previously, hyperpolarized [1-13C]pyruvate have been used to study the metabolic properties of tumor through measuring the rapid conversion of pyruvate to lactate. However, the fate of the 13C-lactate, following the hyperpolarized experiment, has been less understood due to the fast, irreversible decay of the hyperpolarized signal. In this work, lactate concentrations (total, 13C1- and 13C3-lactate) has been estimated in rat tumor extracts following the injection of hyperpolarized [1-13C]pyruvate and non-hyperpolarized [3-13C]pyruvate in rats.

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