Abstract #0472

Correlation of Hyperpolarized 13C-Lactate Measurements and Ex Vivo NMR using a [3-13C]Pyruvate Injection

Casey Y. Lee^1,2, Justin Y. C. Lau^1,2, Albert P. Chen³, Yi-Ping Gu², and Charles H. Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³GE Healthcare, Toronto, ON, Canada

Lactate has been proposed as a potential marker to non-invasively predict cancer progression and monitor response to the therapy. Previously, hyperpolarized [1-¹³C]pyruvate have been used to study the metabolic properties of tumor through measuring the rapid conversion of pyruvate to lactate. However, the fate of the ¹³C-lactate, following the hyperpolarized experiment, has been less understood due to the fast, irreversible decay of the hyperpolarized signal. In this work, lactate concentrations (total, ¹³C₁- and ¹³C₃-lactate) has been estimated in rat tumor extracts following the injection of hyperpolarized [1-¹³C]pyruvate and non-hyperpolarized [3-¹³C]pyruvate in rats.

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