Abstract #0473

Velocity-Selective Tip-Back Excitation for Hyperpolarized [13C] Urea Cardiac Perfusion Imaging

Maximilian Fuetterer¹, Julia Busch¹, Constantin von Deuster^1,2, Christian Binter¹, Nikola Cesarovic³, Miriam Lipiski³, Christian Torben Stoeck^1,2, and Sebastian Kozerke^1,2

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ²Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ³Division of Surgical Research, University Hospital Zurich, Zurich, Switzerland

A velocity-selective excitation scheme with bipolar slice-select gradients for hyperpolarized cardiac perfusion imaging is presented. Using the approach, an excitation ratio of >5 of myocardial signal to left-ventricular blood pool signal can be achieved based on differences in blood and tissue velocities. Thereby increased myocardial signal and reduced left-ventricular signal spilling is obtained. Dynamic perfusion images acquired with hyperpolarized [¹³C]urea in pigs show higher SNR and less signal leakage in the myocardium relative to a conventional excitation approach.

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