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Abstract #0473

Velocity-Selective Tip-Back Excitation for Hyperpolarized [13C] Urea Cardiac Perfusion Imaging

Maximilian Fuetterer1, Julia Busch1, Constantin von Deuster1,2, Christian Binter1, Nikola Cesarovic3, Miriam Lipiski3, Christian Torben Stoeck1,2, and Sebastian Kozerke1,2

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 3Division of Surgical Research, University Hospital Zurich, Zurich, Switzerland

A velocity-selective excitation scheme with bipolar slice-select gradients for hyperpolarized cardiac perfusion imaging is presented. Using the approach, an excitation ratio of >5 of myocardial signal to left-ventricular blood pool signal can be achieved based on differences in blood and tissue velocities. Thereby increased myocardial signal and reduced left-ventricular signal spilling is obtained. Dynamic perfusion images acquired with hyperpolarized [13C]urea in pigs show higher SNR and less signal leakage in the myocardium relative to a conventional excitation approach.

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