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Abstract #0474

Investigating in vivo cardiac ketone bodies metabolism using hyperpolarized 13C acetoacetate

Way Cherng Chen1, Xing Qi Teo1, and Teck Hock Philip Lee1

1Laboratory of metabolic imaging, Singapore Bioimaging Consortium, Singapore, Singapore

The use of hyperpolarized 3-13C acetoacetate to probe in vivo cardiac ketone bodies metabolism was investigated. Preliminary results showed the successful detection of 1-13C citrate and 1-13C acetylcarnitine after hyperpolarized acetoacetate delivery. Specifically, a significant increase in citrate with a corresponding decrease in acetylcarnitine was observed in the rat heart in vivo after 24hrs of fasting.

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