Abstract #0474

Investigating in vivo cardiac ketone bodies metabolism using hyperpolarized 13C acetoacetate

Way Cherng Chen¹, Xing Qi Teo¹, and Teck Hock Philip Lee¹

¹Laboratory of metabolic imaging, Singapore Bioimaging Consortium, Singapore, Singapore

The use of hyperpolarized 3-13C acetoacetate to probe in vivo cardiac ketone bodies metabolism was investigated. Preliminary results showed the successful detection of 1-13C citrate and 1-13C acetylcarnitine after hyperpolarized acetoacetate delivery. Specifically, a significant increase in citrate with a corresponding decrease in acetylcarnitine was observed in the rat heart in vivo after 24hrs of fasting.

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