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Abstract #0475

Dynamic Nuclear Polarization of Biocompatible 13C-Enriched Carbonates for In vivo pH Imaging

David E Korenchan1,2, Robert Flavell1, Renuka Sriram1, Celine Baligand1, Kiel Neumann1, Subramaniam Sukumar1, Daniel B Vigneron1,2, Henry VanBrocklin1, David M Wilson1, and John Kurhanewicz1,2

1Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, United States, 2Bioengineering, University of California at Berkeley, Berkeley, CA, United States

Although large gains in hyperpolarized 13C-bicarbonate signal are obtainable for extracellular pH imaging, toxicity becomes a concern for clinical implementation of current methods. We report an approach in which a precursor molecule, 1,2-glycerol carbonate, is hyperpolarized and decomposed to form bicarbonate, CO2, and glycerol using base-catalyzed hydrolysis. This technique enables concentrations and polarizations similar to those previously reported, and its application to pH imaging, both in phantom experiments and in vivo in a mouse model of prostate cancer, is demonstrated.

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