Abstract #0475

Dynamic Nuclear Polarization of Biocompatible 13C-Enriched Carbonates for In vivo pH Imaging

David E Korenchan^1,2, Robert Flavell¹, Renuka Sriram¹, Celine Baligand¹, Kiel Neumann¹, Subramaniam Sukumar¹, Daniel B Vigneron^1,2, Henry VanBrocklin¹, David M Wilson¹, and John Kurhanewicz^1,2

¹Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, United States, ²Bioengineering, University of California at Berkeley, Berkeley, CA, United States

Although large gains in hyperpolarized ¹³C-bicarbonate signal are obtainable for extracellular pH imaging, toxicity becomes a concern for clinical implementation of current methods. We report an approach in which a precursor molecule, 1,2-glycerol carbonate, is hyperpolarized and decomposed to form bicarbonate, CO₂, and glycerol using base-catalyzed hydrolysis. This technique enables concentrations and polarizations similar to those previously reported, and its application to pH imaging, both in phantom experiments and in vivo in a mouse model of prostate cancer, is demonstrated.

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