Abstract #0478

Functionalized Cryptophane-129Xe MRI Biosensor for Biothiols Detection through Thiol-addition Reaction

Shengjun Yang¹, Weiping Jiang¹, Qing Luo¹, Qianni Guo¹, and Xin Zhou¹

¹Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of

Biothiols such as cysteine, homocysteine and glutathione play an important role in regulating the vital functions of living organisms. Here, we report a biosensor for biothiol detection and imaging using nuclear spin resonance of 129Xe. The 129Xe biosensor consists of cryptophane-A cage encapsulating xenon atom and acrylate group. The latter serves as a reactive site to covalently bond biothiols through thiol-addition reaction. The selectivity of the biosensor enables discrimination of Cys from Hcy and GSH through the chemical reaction rate. Our results indicate that this biosensor is a promising strategy for the real-time imaging of biothiol distributions.

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