Abstract #0479

Deciphering the Functional Role of Locus Coeruleus-derived Norepinephrine using Chemogenetic fMRI and 18FDG-PET

Esteban Adrian Oyarzabal^1,2, Manasmita Das³, Sung-Ho Adrian Lee⁴, Natale Sciolino², Irina Evsyukova², Patricia Jensen², and Yen-Yu (Ian) Shih³

¹Neurology, UNC-Chapel Hill, Carrboro, NC, United States, ²Laboratory of Neurobiology, NIEHS/NIH, Research Triangle Park, NC, United States, ³Neurology, UNC-Chapel Hill, Chapel Hill, NC, United States, ⁴UNC-Chapel Hill, Chapel Hill, NC, United States

This study examines how selective chemogenetic stimulation of noradrenergic neurons of the Locus Coeruleus (LC) in mice modulates cerebral metabolism and vascular tone. This was achieved by using a transgenic mouse line selectively expresses Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in the LC noradrenergic neurons. A multimodal imaging approach was used, with MRI being used to evaluate hemodynamic changes and PET being used to assess glucose metabolism.

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