Xuming Chen1,2, Hellmut Merkle1, and Xin Yu1
1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Neurology, Renmin Hospital of Wuhan University, Wuhan, China, People's Republic of
Previously, we
have developed a single-vessel fMRI method to visualize the hemodynamic signal
propagation from individual venules and arterioles in the deep layer cortex.
Here, we combined single-vessel fMRI with optogenetic
photo-activation to map vessel-specific fMRI signal from the rat hippocampus. A
MGE sequence was used to distinguish the individual arterioles and venules
penetrating the main structure of the hippocampus. The BOLD-fMRI signal was mapped
to overlap with the individual venules. This result makes it possible to study
the coupled neuronal and vascular interaction in the focal hippocampal stroke
rat model, which may mimic the pathophysiological basis of transient global
amnesia in human.
