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Abstract #0480

Light-driven single-vessel fMRI on the rat hippocampus

Xuming Chen1,2, Hellmut Merkle1, and Xin Yu1

1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Neurology, Renmin Hospital of Wuhan University, Wuhan, China, People's Republic of

Previously, we have developed a single-vessel fMRI method to visualize the hemodynamic signal propagation from individual venules and arterioles in the deep layer cortex. Here, we combined single-vessel fMRI with optogenetic photo-activation to map vessel-specific fMRI signal from the rat hippocampus. A MGE sequence was used to distinguish the individual arterioles and venules penetrating the main structure of the hippocampus. The BOLD-fMRI signal was mapped to overlap with the individual venules. This result makes it possible to study the coupled neuronal and vascular interaction in the focal hippocampal stroke rat model, which may mimic the pathophysiological basis of transient global amnesia in human.

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