Abstract #0481

Combined auditory and optogenetic fMRI for investigation of visual cortical descending modulation of auditory midbrain processing

Patrick P. Gao^1,2, Russell W. Chan^1,2, Alex T.L. Leong^1,2, Celia M. Dong^1,2, and Ed X. Wu^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, China, People's Republic of, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, People's Republic of

In the auditory system, the midbrain inferior colliculus (IC) receives massive corticofugal projections, yet their functional implications remain unclear. Previous studies utilizing single neuron recordings and electrical activation or cryogenical inactivation of the cortex could not provide a cell-type specific understanding of the large-scale corticofugal modulation effects. This study combines auditory and optogenetic fMRI to investigate the corticofugal influences on auditory midbrain processing. Large-view fMRI was used to monitor the IC noise response during cell-type specific optogenetic stimulation of the VC. The results demonstrate the feasibility of this novel approach and show that VC normally facilitates auditory midbrain responses.

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