Abstract #0485

Study of the Transfer Functions of Hippocampal Subfields during a Spatial Memory Task using High-Resolution fMRI

Xiaowei Zhuang¹, Zhengshi Yang¹, Tim Curran², and Dietmar Cordes^1,2

¹Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ²Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States

In this abstract, the input/output transfer relationship in human hippocampal subfields (mainly CA1, CA3, and DG) was studied using fMRI during a spatial memory task with increments in the change of FOV in the stimuli. Whole brain activation was obtained for all lure v/s control contrasts. Mean activation t value for each hippocampal subregions (CA1, CA2&3 and CA4&DG) was extracted, averaged over all the subjects and plotted against FOV changes to compare with the existing models. K-means clustering was then applied. Data from one of the k-means clusters showed a pattern separation/completion curve similar to the animal model.

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