Meeting Banner
Abstract #0485

Study of the Transfer Functions of Hippocampal Subfields during a Spatial Memory Task using High-Resolution fMRI

Xiaowei Zhuang1, Zhengshi Yang1, Tim Curran2, and Dietmar Cordes1,2

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, United States

In this abstract, the input/output transfer relationship in human hippocampal subfields (mainly CA1, CA3, and DG) was studied using fMRI during a spatial memory task with increments in the change of FOV in the stimuli. Whole brain activation was obtained for all lure v/s control contrasts. Mean activation t value for each hippocampal subregions (CA1, CA2&3 and CA4&DG) was extracted, averaged over all the subjects and plotted against FOV changes to compare with the existing models. K-means clustering was then applied. Data from one of the k-means clusters showed a pattern separation/completion curve similar to the animal model.

This abstract and the presentation materials are available to members only; a login is required.

Join Here