Abstract #0486

Visualizing adaptation of the central serotonin circuit in the living brain

Bechara J. Saab¹, Joanes Grandjean², Alberto Corcoba³, Martin C. Kahn⁴, Louise A. Upton⁴, Erich Seifritz¹, Fritjof Helmchen⁵, Isabelle Mansuy¹, Edward O. Mann⁴, and Markus Rudin²

¹University of Zurich, Zurich, Switzerland, ²University and ETH Zurich, Zurich, Switzerland, ³EPFL, Lausanne, Switzerland, ⁴University of Oxford, Oxford, United Kingdom, ⁵University and ETH Zurich, Zuerich, Switzerland

Mouse functional MRI was used to investigate the effect of selective stimulation of serotonergic neurons of the dorsal raphe via channelorodopsin-mediated optical control. Electrophysiological recordings in the nucleus and in projection areas confirmed neuronal activity changes upon illumination with blue light. Acute pharmacological modulation with fluoxetine, a serotonin reuptake inhibitor, lead to increased CBV response upon 5HT release, while animal restraint prior to measurements lead to a reduction of the elicited response. This study demonstrates the feasibility to assess a neurotransmitter function non-invasively at a whole brain level and investigate alterations in mood-controlling systems.

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