Multiparametric MRI Characterization of Magnetic Viral Complexes
Alexander Joos1, Olga Mykhaylyk2, Norbert Löwa3, Dietmar Eberbeck3, Bernhard Gleich1, and Axel Haase1
1Zentralinstitut für Medizintechnik der Technischen Universität München, Garching, Germany, 2Department of Experimental Oncology, Klinikum rechts der Isar der TU München, Munich, Germany, 3Physikalisch-Technische Bundesanstalt, Berlin, Germany
nanoparticles can be used for magnetic drug targeting while MRI can
serve as non-invasive therapy monitoring. We investigated the
influence of the assembling of magnetic nanoparticles with oncolytic
viruses and their uptake into cancer cells on the MRI relaxivities
r1, r2 and r2* and magnetically characterized all samples using
magnetic particle spectroscopy. Our results show that R2*
measurements seem most suitable for particle quantification while R2
is sensitive to the uptake of the particles into the cells. Magnetic
particle spectroscopy proves to be an important validation technique
for MRI relaxometry.
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