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Abstract #0499

Multiparametric MRI Characterization of Magnetic Viral Complexes

Alexander Joos1, Olga Mykhaylyk2, Norbert Löwa3, Dietmar Eberbeck3, Bernhard Gleich1, and Axel Haase1

1Zentralinstitut für Medizintechnik der Technischen Universität München, Garching, Germany, 2Department of Experimental Oncology, Klinikum rechts der Isar der TU München, Munich, Germany, 3Physikalisch-Technische Bundesanstalt, Berlin, Germany

Magnetic nanoparticles can be used for magnetic drug targeting while MRI can serve as non-invasive therapy monitoring. We investigated the influence of the assembling of magnetic nanoparticles with oncolytic viruses and their uptake into cancer cells on the MRI relaxivities r1, r2 and r2* and magnetically characterized all samples using magnetic particle spectroscopy. Our results show that R2* measurements seem most suitable for particle quantification while R2 is sensitive to the uptake of the particles into the cells. Magnetic particle spectroscopy proves to be an important validation technique for MRI relaxometry.

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