Abstract #0499

Multiparametric MRI Characterization of Magnetic Viral Complexes

Alexander Joos¹, Olga Mykhaylyk², Norbert Löwa³, Dietmar Eberbeck³, Bernhard Gleich¹, and Axel Haase¹

¹Zentralinstitut für Medizintechnik der Technischen Universität München, Garching, Germany, ²Department of Experimental Oncology, Klinikum rechts der Isar der TU München, Munich, Germany, ³Physikalisch-Technische Bundesanstalt, Berlin, Germany

Magnetic nanoparticles can be used for magnetic drug targeting while MRI can serve as non-invasive therapy monitoring. We investigated the influence of the assembling of magnetic nanoparticles with oncolytic viruses and their uptake into cancer cells on the MRI relaxivities r₁, r₂ and r₂^* and magnetically characterized all samples using magnetic particle spectroscopy. Our results show that R₂^* measurements seem most suitable for particle quantification while R₂ is sensitive to the uptake of the particles into the cells. Magnetic particle spectroscopy proves to be an important validation technique for MRI relaxometry.

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