Abstract #0507

Rotating frame MRI in human subjects with Multiple Sclerosis

Silvia Mangia¹, Alena Svatkova^2,3, Peter Bednarik^1,3, Igor Nestrasil², Lynn E. Eberly⁴, Adam Carpenter⁵, and Shalom Michaeli¹

¹Radiology, CMRR, University of Minnesota, Minneapolis, MN, United States, ²Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, ³Central European Institute of Technology, Masaryk University, Brno, Czech Republic, ⁴Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States, ⁵Neurology, University of Minnesota, Minneapolis, MN, United States

Rotating frame MRI methods including adiabatic T1ρ, T2ρ, and RAFF4 were here employed for characterizing the white matter (WM) of relapsing-remitting Multiple Sclerosis (MS) patients. We calculated relaxograms from subcortical WM of MS patients (excluding lesions) and age-matched controls, and compared them with histograms of DTI outcomes. T1ρ, T2ρ and TRAFF4 were significantly different in the WM of MS patients vs controls, while DTI outcomes did not detect group differences. These findings are supported by recent validation studies using demyelination/dysmyelination animal models, where RAFF4 exhibited exceptional ability to probe myelin content/integrity which we attribute to enhanced sensitivity to slow/ultra-slow motion.

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