Abstract #0508

R2’ is the Best Transverse Relaxation Rate for Oxygenation Mapping: Experience in Moyamoya Disease with Acetazolamide Challenge

Wendy Ni^1,2, Thomas Christen², and Greg Zaharchuk²

¹Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ²Department of Radiology, Stanford University, Stanford, CA, United States

Transverse MR spin relaxation rates, R₂*, R₂ and R₂’ have all been considered sensitive to brain tissue oxygenation. In this study, we focus on a cohort of pre-operative Moyamoya disease patients and simultaneously map all three rates in addition to cerebral blood flow, both before and after the injection of the vasodilatory drug, acetazolamide. We found our measurements to be consistent with physiology and previous studies, and to support the use of R₂’ for oxygenation mapping instead of R₂* and R₂.

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