Abstract #0509

Deep brain nuclei T1 shortening after gadolinium in children: influence of radiation and chemotherapy

Sonja Kinner^1,2, Tilman B Schubert^1,3, Susan Rebsamen¹, Richard Bruce¹, Scott B Reeder^1,4,5,6,7, and Howard A Rowley¹

¹Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ²Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany, ³Clinic for Radiology and Nuclear Medicine, Basel University Hospital, Basel, Switzerland, ⁴Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁵Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁶Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ⁷Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States

Recent studies report intrinsic T1 hyperintense signal in deep brain nuclei on MRI after multiple doses of gadolinium-based contrast agents in adults. We investigated whether similar T1 shortening was also found in children, and furthermore evaluated the influence of radiochemotherapy (RCTX) on its appearance. Signal increases were found in 2/60 children without RCTX and in 12/16 children with RCTX. Signal ratio changes were significantly different between the two groups and appeared with fewer doses in children with RCTX.

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