Abstract #0510

T1 relaxometry indicate cerebral gadolinium retention after multiple administration of a macrocyclic Gd-based contrast agent: A Retrospective Study in 27 patients with Glioblastoma Multiforme

Svein Are Vatnehol¹, Inge Rasmus Groote¹, Christopher Larsson¹, Magne Kleppestø¹, Jonas Vardal¹, and Atle Bjørnerud^1,2

¹The Intervention Center, Oslo University Hospital, Oslo, Norway, ²Department of Physics, University of Oslo, Oslo, Norway

Recent publications have shown an increase in signal intensity on non-enhanced T1w-images for the Dentate Nucleus and Globus Pallidus. This effect seems to be linked to multiple administrations of linear gadolinium chelate. In this retrospective study we have analyzed the quantitative T1 values (qT1) and the normalized native T1 signal intensity (nSI) for the Globus Pallidus and the nSI for the Dentate Nucleus in patients with multiple injections of gadobutrol (Gadovist™). Our analysis suggest a significant change in the qT1 and nSI for the Globus Pallidus as well as in the nSI for the Dentate Nucleus

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