Meeting Banner
Abstract #0512

T1-weighted signal increase in the rat brain after multiple, high-dose administrations of gadolinium based contrast agents:  Comparison of linear and macrocyclic agents

Gregor Jost1, Diana Lenhard2, Jessica Lohrke1, Thomas Frenzel1, and Hubertus Pietsch1

1MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany, 2Institute of Vegetative Physiology, Charité, Berlin, Germany

Recent publications reported increased T1-weighted (T1w) signal intensities (SI) in the dentate nucleus and globus pallidus after repeated administrations of gadolinium based contrast agents (GBCAs). In the present animal study the T1w SI of three linear and two macrocyclic GBCAs were systematically evaluated after ten administrations each with a dose of 2.5 mmol/kg. Increased cerebellar nuclei to pons SI ratios were found after administration of linear GBCAs (significantly increased for gadodiamide and gadobenate dimeglumine, and non-significantly increased for gadopentetate dimeglumine). In contrast no elevated SI ratios were observed after administration of the macrocyclic GBCAs gadobutrol and gadoterate meglumine or saline.

This abstract and the presentation materials are available to members only; a login is required.

Join Here