Abstract #0512

T1-weighted signal increase in the rat brain after multiple, high-dose administrations of gadolinium based contrast agents: Comparison of linear and macrocyclic agents

Gregor Jost¹, Diana Lenhard², Jessica Lohrke¹, Thomas Frenzel¹, and Hubertus Pietsch¹

¹MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany, ²Institute of Vegetative Physiology, Charité, Berlin, Germany

Recent publications reported increased T1-weighted (T1w) signal intensities (SI) in the dentate nucleus and globus pallidus after repeated administrations of gadolinium based contrast agents (GBCAs). In the present animal study the T1w SI of three linear and two macrocyclic GBCAs were systematically evaluated after ten administrations each with a dose of 2.5 mmol/kg. Increased cerebellar nuclei to pons SI ratios were found after administration of linear GBCAs (significantly increased for gadodiamide and gadobenate dimeglumine, and non-significantly increased for gadopentetate dimeglumine). In contrast no elevated SI ratios were observed after administration of the macrocyclic GBCAs gadobutrol and gadoterate meglumine or saline.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.