Abstract #0513

Regional uptake and clearance of Gd(III) DTPA in the healthy adult mouse brain

Daniel Calle¹, Irene Guadilla¹, Pilar López-Larrubia¹, and Sebastián Cerdán¹

¹Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC, Madrid, Spain

We report on the kinetics of uptake and clearance of Gd(III)DTPA from different brain structures to healthy mice. We fitted a biexponential model to cerebral time courses of increase and decrease of T_1w MRI signal intensity, calculating rate constants for the uptake (k_abs) and elimination (k_el). k_absshowed the rapid absorption in the ventricles and hypothalamus, slowing down significantly in the cortex, globus pallidus and dentante nucleus. These latter structures required 617 h. (cortex), 245 h. (globus pallidus) and approximately 100h (hypothalamus and dentate nucleus), to remove 99% of the administered agent, revealing very high cerebral residence times of Magnevist.

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