Abstract #0514

Contrast enhancement of perivascular spaces in the basal ganglia

Shinji Naganawa¹ and Toshiaki Taoka¹

¹Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Perivascular spaces (PVS) have been described as non-enhancing structures with a fluid signal. In this study, we confirmed that PVS signals are enhanced in images obtained 4 hours after intravenous administration of gadolinium based contrast agent (GBCA) in human subjects without renal insufficiency. Contrast enhancement of CSF was also observed. It is possible that GBCA in the blood vessels might have permeated into the CSF space and PVS. This could be the route by which GBCA is distributed to brain parenchyma through the glymphatic system in subjects with a normal blood brain barrier.

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