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Abstract #0515

Regional and global assessment on relaxometric quantitative MRI in patients with previous administration of a linear gadolinium-based contrast agent

Hirofumi Kuno1, Hernan Jara1, Karen Buch1, Andrew Mills1, Muhammad Mustafa Quresh1, Neil Thayil 1, Margaret N Chapman1, and Osamu Sakai1

1Radiology, Boston University, Boston Medical Center, Boston, MA, United States

To assess potential regional and global correlations between brain relaxation times and the number of prior administrations of linear gadolinium-based contrast agents (GBCA) using quantitative MRI. The subjects consisted of 40 patients (7 patients with multiple prior linear GBCA exposures and 33 patients with no prior GBCA exposures) with brain MRI using the mixed turbo spin-echo pulse sequence. T1 and T2 relaxation times were assessed in selected regions of brain parenchyma (GP, DN, thalamus, and pons) and the whole brain, and were demonstrated to be associated with the number of gadolinium administrations. A stronger relationship was demonstrated in gray matter.

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