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Abstract #0532

Repeatability of MRI and MRS pancreatic proton density fat fraction (PDFF) quantification methods

Alexandra N Schlein1, Yesenia Covarrubias1, Adrija Mamidipalli1, Jonathan Hooker1, Michael S Middleton1, Rohit Loomba2, Tanya Wolfson3, Claude B Sirlin1, and Gavin Hamilton1

1Radiology, UCSD, San Diego, CA, United States, 2Hepatology, UCSD, San Diego, CA, United States, 3Computational and Applied Statistics Laboratory UCSD, San Diego, CA, United States

Advanced MR techniques have been developed to estimate proton density fat fraction (PDFF) of pancreatic fat. The purpose of this study is to assess intra- and inter-examination repeatability of 1H MRS and multi-echo MRI to estimate pancreatic PDFF. Subjects were scanned with both MRI and MRS three times: twice without subject repositioning and then once more after having subjects get off and back on the table. The results suggest that MRI is more repeatable than MRS, especially when subjects are repositioned between acquisitions, which more closely simulates the conditions in which these techniques might be applied clinically and in research.

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