Abstract #0535

Longitudinal change of pancreatic proton density fat fraction (PDFF) and its correlates during weight loss in initially obese adults

Yesenia Covarrubias¹, Alexandra N Schlein¹, William M Haufe¹, Catherine A Hooker¹, Adrija Mamidipalli¹, Tanya Wolfson², Garth Jacobson³, Santiago Horgan³, Jeffrey B Schwimmer⁴, Scott B Reeder⁵, and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, University of California, San Diego, School of Medicine, San Diego, CA, United States, ²Computational and Applied Statistics Laboratory (CASL), SDSC, University of California, San Diego, La Jolla, CA, United States, ³Department of Surgery, University of California, San Diego, La Jolla, CA, United States, ⁴Division of Gastroenterology, Hepatology, and Nutrition & Department of Pediatrics, University of California, San Diego, School of Medicine, San Diego, CA, United States, ⁵Departments of Radiology, Medical Physics, Biomedical Engineering, Medicine, Emergency Medicine, University of Wisconsin, Madison, WI, United States

This pilot, prospective, longitudinal study in 9 obese adults explored the relationship between weight loss and longitudinal change in MRI-determined pancreatic proton density fat fraction (PDFF), as well as the relationships between rates of change in pancreatic PDFF, hepatic PDFF, and anthropometric measures. Pancreatic PDFF decreased in every subject from a mean of 15.5% at the first study visit to a mean of 8.6% at the last study visit (p=0.006). Further research in larger cohorts is needed to confirm our findings and to understand the clinical and biological relevance of pancreatic PDFF reduction.

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