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Abstract #0534

Impact of Inter-lobular Fat on the Repeatability of Pancreatic Fat Fraction Measurement by MRI.

Adam Jaster1, Ivan Pedrosa1,2, Robert E. Lenkinski1,2, Ildiko Lingvay3,4, and Takeshi Yokoo1,2

1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States, 4Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, United States

In pancreatic steatosis, fat accumulates within intra-lobular (parenchyma) and inter-lobular (adipose) tissue. Regions of interest (ROIs) placed in pancreas include heterogeneous population of pixels of lower-fat intra-lobular tissue, higher-fat inter-lobular tissue, and admixture of the two by partial volume effects. In this study of 21 subjects with insulin-dependent type 2 diabetes, we investigated the impact of inter-lobular fat on the repeatability of pancreatic fat fraction (FF) measurement by multiecho gradient-echo MRI. We found that the mean FF measurement within segmented pancreatic ROI is highly repeatable with intraclass correlation of 0.965 after exclusion of high-fat (FF≥50%) pixels contaminated by inter-lobular fat.

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