Abstract #0539

Use of comprehensive MRI to assess cartilage composition in patients with acute cartilage injury

Didier Laurent¹, Stefan Zbyn², Vladimir Mlynarik², Markus Schreiner², Pavol Szomolanyi², Nicole Getzmann¹, Harry Haber¹, Joerg Goldhahn¹, Stefan Marlovits³, and Siegfried Trattnig²

¹Novartis Institutes fo Biomedical Research, Basel, Switzerland, ²Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ³Department of Traumatology, Medical University of Vienna, Vienna, Austria

A comprehensive MRI approach was implemented to assess cartilage macromolecular composition in patients with acute cartilage injury. Differences in T2 relaxation and gagCEST asymmetry values were observed between the defective and adjacent regions in the tibio-femoral cartilage. Preliminary results indicate that the combination of T2 mapping with gagCEST scans at 7T may be reproducible and sensitive enough to monitor early cartilage degeneration, and thus may be considered as a good alternative to cartilage biopsies in future clinical trials on new therapies aimed at cartilage regeneration.

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