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Abstract #0539

Use of comprehensive MRI to assess cartilage composition in patients with acute cartilage injury

Didier Laurent1, Stefan Zbyn2, Vladimir Mlynarik2, Markus Schreiner2, Pavol Szomolanyi2, Nicole Getzmann1, Harry Haber1, Joerg Goldhahn1, Stefan Marlovits3, and Siegfried Trattnig2

1Novartis Institutes fo Biomedical Research, Basel, Switzerland, 2Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3Department of Traumatology, Medical University of Vienna, Vienna, Austria

A comprehensive MRI approach was implemented to assess cartilage macromolecular composition in patients with acute cartilage injury. Differences in T2 relaxation and gagCEST asymmetry values were observed between the defective and adjacent regions in the tibio-femoral cartilage. Preliminary results indicate that the combination of T2 mapping with gagCEST scans at 7T may be reproducible and sensitive enough to monitor early cartilage degeneration, and thus may be considered as a good alternative to cartilage biopsies in future clinical trials on new therapies aimed at cartilage regeneration.

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