Abstract #0540

A New High-resolution 3D gagCEST Imaging method for In Vivo Human Knee Cartilage at 7T

Guruprasad Krishnamoorthy¹, Ravi Prakash Reddy Nanga¹, Puneet Bagga¹, Hari Hariharan¹, and Ravinder Reddy¹

¹Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Osteoarthritis (OA), one of the most prevalent musculoskeletal conditions, affects a large number of people around the world with an increased risk on an even larger number of people getting affected by it in the future [1]. GAG chemical exchange saturation transfer (gagCEST) is a promising MRI technique to non-invasively quantify GAG content present in the cartilages [2]. In this study, a new burst mode magnetization preparation 3D gagCEST technique was developed which provided high-resolution gagCEST maps of knee cartilages in practically achievable scan times at 7T with more than twice the sensitivity of the previously reported steady-state saturation 3D gagCEST study [5].

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