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Abstract #0540

A New High-resolution 3D gagCEST Imaging method for In Vivo Human Knee Cartilage at 7T

Guruprasad Krishnamoorthy1, Ravi Prakash Reddy Nanga1, Puneet Bagga1, Hari Hariharan1, and Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Osteoarthritis (OA), one of the most prevalent musculoskeletal conditions, affects a large number of people around the world with an increased risk on an even larger number of people getting affected by it in the future [1]. GAG chemical exchange saturation transfer (gagCEST) is a promising MRI technique to non-invasively quantify GAG content present in the cartilages [2]. In this study, a new burst mode magnetization preparation 3D gagCEST technique was developed which provided high-resolution gagCEST maps of knee cartilages in practically achievable scan times at 7T with more than twice the sensitivity of the previously reported steady-state saturation 3D gagCEST study [5].

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