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Abstract #0554

White-Matter-Nulled MP-RAGE Predicts Clinical Outcome of Focused Ultrasound Thalamic Ablation for Essential Tremor

Jason Su1, Christian Federau2, Thomas Tourdias3, Manojkumar Saranathan4, Casey Halpern5, Jaimie Henderson5, Veronica Santini6, Kim Butts-Pauly2, Pejman Ghanouni2, and Brian Rutt2

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Neuroradiology, Bordeaux University Hospital, Bordeaux, France, 4Radiology, University of Arizona, Tucson, AZ, United States, 5Neurosurgery, Stanford University, Stanford, CA, United States, 6Neurology, Stanford University, Stanford, CA, United States

This retrospective analysis of MR-guided focused ultrasound ablation for essential tremor (ET) treatment is centered on clinical outcome (CRST A+B) and segmentation of ablation lesions using the white-matter-nulled MP-RAGE contrast. There is no significant correlation between the volume of ablation and clinical outcome at 1 month. We identify a new potential target region based on the best-responding patient and compute the percent coverage of that region by each subject’s ablation via nonlinear registration. This measure correlates with the outcome after 1 month in 8 subjects with r2=0.8 and p=0.003, a remarkable association that may aid future targeting strategies in ET.

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