Abstract #0555

Evaluation of thermal ablation with a 230 kHz transcranial MRI-guided focused ultrasound system in a large animal model

Nathan McDannold¹, Jonathan Sutton¹, Natalia Vykhodtseva¹, and Margaret Livingstone²

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Neurobiology, Harvard Medical School, Boston, MA, United States

This work evaluated the feasibility of thermal ablation in the brain in nonhuman primates using a 230 kHz transcranial MRI-guided focused ultrasound system. We aimed to determine whether using this low frequency can expand the treatment envelope where focused ultrasound can be used in the brain without overheating the skull. We found that focal heating was increased and skull heating decreased compared to prior work in macaques that tested a higher frequency version of this system, suggesting that it can indeed increase this envelope. Furthermore, closed-loop feedback maintained a low level of cavitation activity.

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