Quantitative Determination of Pediatric Myelination Using Fast Bound-Pool Fraction Imaging
Hunter R Underhill1,2 and Gary Hedlund2
1Pediatrics, University of Utah, Salt Lake City, UT, United States, 2Radiology, University of Utah, Salt Lake City, UT, United States
Fast bound-pool
fraction imaging (FBFI) is a quantitative MRI technique validated with
histology to measure whole-brain, voxel-based myelin density. In this study,
FBFI was translated to a whole-body 3T clinical scanner using only standard preset
sequences without modifications to measure myelin density in the developing pediatric
brain via a time-efficient methodology (<7 min). We found that FBFI
effectively quantifies myelin density during normal development. Progressive
myelination identified in the posterior white matter corresponded strongly to a
bounded exponential growth curve. Quantification of myelin density with FBFI in
pediatric patients may improve detection of delayed or altered myelination.
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