Abstract #0557

Quantitative Determination of Pediatric Myelination Using Fast Bound-Pool Fraction Imaging

Hunter R Underhill^1,2 and Gary Hedlund²

¹Pediatrics, University of Utah, Salt Lake City, UT, United States, ²Radiology, University of Utah, Salt Lake City, UT, United States

Fast bound-pool fraction imaging (FBFI) is a quantitative MRI technique validated with histology to measure whole-brain, voxel-based myelin density. In this study, FBFI was translated to a whole-body 3T clinical scanner using only standard preset sequences without modifications to measure myelin density in the developing pediatric brain via a time-efficient methodology (<7 min). We found that FBFI effectively quantifies myelin density during normal development. Progressive myelination identified in the posterior white matter corresponded strongly to a bounded exponential growth curve. Quantification of myelin density with FBFI in pediatric patients may improve detection of delayed or altered myelination.

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