Abstract #0558

Longitudinal Probing Infant Brain Connectomes Using Graph Theory

Longchuan Li^1,2, Sarah Shultz¹, Xiaoping Hu², Ami Klin¹, and Warren Jones¹

¹Marcus Autism Center, Emory University, Atlanta, GA, United States, ²Biomedical Imaging Technology Center, Emory University, Atlanta, GA, United States

We used diffusion tractography and network theory to examine the organizational development of the brain in typical infants in their first 6 months of life. Data were longitudinally sampled at randomized time points between birth and 6 months and collected on a Siemens 3T TIM Trio system with 32-channel coil using multiband techniques. We found that network-based metrics may reveal unique information in the organizational principles of the brain and its development that is impossible with conventional methods focusing on specific pathways and regions, demonstrating the usefulness of the approach in studying early typical brain development and its disruptions.

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