Abstract #0559

Toward routine assessment of cerebral blood flow in neonates and infants: a phase-contrast MRI study

Peiying Liu¹, Ying Qi², Zixuan Lin¹, Xuna Zhao³, Qiyong Guo², Xiaoming Wang², and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Shengjing Hospital of China Medical University, Shenyang, China, People's Republic of, ³Philips Healthcare, Beijing, China, People's Republic of

Knowledge of CBF in neonates or infants may provide valuable information in many pathological conditions. When applied to very young children, CBF mapping using arterial-spin-labeling (ASL) MRI suffers from low SNR and poor quantification, whereas phase-contrast (PC) MRI may provide reliable estimation of global CBF. Therefore, this study aim to 1) provide a set of age-specific PC-MRI protocols for CBF quantification in children under 1.5 years old; 2) establish typical arterial flow velocity in children at this age which could guide future ASL efforts in labeling pulse optimization; 3) report how CBF changes during this early stage of life.

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