Abstract #0560

Global and regional cortical connectivity maturation index (CCMI) of developmental human brain with quantification of short-range association tracts

Minhui Ouyang¹, Tina Jeon¹, Jennifer Muller¹, Virendra Mishra², Haixiao Du³, Yu Wang³, Yun Peng⁴, Bo Hong⁵, and Hao Huang^1,6

¹Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, ³Department of Electronic Engineering, Tsinghua University, Beijing, China, People's Republic of, ⁴Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China, People's Republic of, ⁵Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, ⁶Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Disturbance of precisely balanced strengthening of certain axons and pruning of others in developmental human brains is associated with mental disorders such as autism and schizophrenia. To characterize this balance, we defined a cortical connectivity maturation index (CCMI) derived from short-range association tracts traced with diffusion MRI tractography. The brain CCMI values were measured with diffusion MRI and T₁-weighted datasets of 21 healthy subjects with age of 2-25 years. CCMI in all cortical regions decreased in early developmental stage and increased later, yet with distinctive trajectories. The observed CCMI dynamics may be underlaid by heterogeneous pruning among cortical regions.

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