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Abstract #0562

Age-related Magnetic Susceptibility in the Deep Gray Nuclei from 1 month to 6 Years: Comparison between Quantitative Susceptibility and R2* Mapping

Ning Ning1, Peng Wu2, Xianjun Li3, Yajie Hu3, Weishan Zhang1, Lei Zhang1, Sung-Min Gho4, Dong-Hyun Kim4, Hua Guo2, and Jian Yang1,3

1Department of Diagnostic Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China, People's Republic of, 2Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, 3Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China, People's Republic of, 4Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea, Republic of

To observe the age-related susceptibility changes in the deep gray nuclei and assess the superiority of the quantitative susceptibility mapping(QSM) and effective transverse relaxation rate(R2*) for quantifying the iron deposits in children. 87 subjects(1M-6Y) were enrolled. The susceptibility in QSM and R2* values exhibited positive correlations with age and the reference iron concentrations calculated using an empirical equation. The correlation of the susceptibility with the iron is higher than the R2* with it. QSM may provide a more promising and reliable tool for assessment of iron content in children’s deep gray nuclei, even in the regions with lower iron content.

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