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Abstract #0563

To smell or not to smell: does the newborn habituate to sustained odorant stimulation?

Frédéric Grouiller1, Alexandra Adam-Darqué2, Russia Ha-Vinh Leuchter2, Petra S Hüppi2, and François Lazeyras1

1Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, 2Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland

The aim of this study is to better characterize the habituation effect of sustained odorant stimulation and to investigate if this effect is already present in newborns. Olfactory fMRI was acquired in adults and newborns using a 20s block design. After modelling habituation, activations in the primary and secondary olfactory cortices were observed in adults and newborns. Habituation effect to sustained odorant stimulation was strong in adults but unseen in the newborns. This study shows that the olfactory cortex of newborns is highly functional soon after birth and that the habituation effect is not observed in newborns compared to adults.

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